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Molecular control of neural differentiation by human pluripotent stem cells
Reference
G16231
Principal Investigator / Supervisor
Professor Stefan Przyborski
Co-Investigators /
Co-Supervisors
Institution
Durham University
Department
Biological and Biomedical Sciences
Funding type
Research
Value (£)
188,724
Status
Completed
Type
Research Grant
Start date
01/05/2002
End date
01/05/2005
Duration
36 months
Abstract
Human pluripotent stem cells serve as important tools for research into human neural development and as a potential source of material for therapeutic purposes. However, our ability to direct the differentiation of such stem cells into particular neural lineages is limited and there is little understanding of the molecular mechanisms involved. First, we propose to assess the effect of specific growth factors that are known to influence neural development on the differentiation of human pluripotent stem cells. Second, we will examine the molecular mechanisms controlling human neural development under conditions defined in part one. We will focus on basic helix-loop-helix transcription factors and first examine their transcriptional profile prior to assessing their function during human neural differentiation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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