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Integrative viral genomics:Investigation of immune mediated reversible inhibitory pathways of a virus replication cycle
Reference
G16026
Principal Investigator / Supervisor
Professor Peter Ghazal
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Medical Physics
Funding type
Research
Value (£)
349,412
Status
Completed
Type
Research Grant
Start date
01/12/2001
End date
01/12/2004
Duration
36 months
Abstract
This project addresses a fundamental question in pathogen biology, latency, by exploring host-pathogen interaction at the global gene transcription level. Microarray technology affords the possibility to identify even subtle phenotypic changes by direct or indirect effects on expression levels. We propose to combine and integrate host and pathogen DNA microarray analysis of a murine cytomegalovirus infection and its reversible inhibition by interferons. The development of bioinformatic and computational tools in establishing an integrated relational database will assist in determining host-virus gene interactions. These studies are likely to provide important insights and methodology toward integrating gene interaction networks in general.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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