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Adult hair follicle dermal stem cells: an investigation of their haematopoietic and reprogramming potential
Reference
G16020
Principal Investigator / Supervisor
Dr Nicholas Hole
Co-Investigators /
Co-Supervisors
Professor Colin Jahoda
,
Professor Majlinda Lako
Institution
Durham University
Department
Biological and Biomedical Sciences
Funding type
Research
Value (£)
254,080
Status
Completed
Type
Research Grant
Start date
11/02/2002
End date
11/02/2005
Duration
36 months
Abstract
We have discovered that adult hair follicle dermal cell populations have haematopoietic stem cell (HSC) potential. This project will characterise this dermal haematopoietic commitment and examine its role under steady state and stressed haematopoiesis. We will a) determine the dynamics of dermal haematopoietic commitment, b) identify the role of this commitment in vivo, c) study the role of the follicle microenvironment in supporting haematopoiesis, and d) examine the trafficking of dermal derived HSC. These data will identify the biological relevance of dermal-derived HSC activity, help our understanding of somatic stem cell reprogramming, and define this as a new model to identify the mechanisms involved in commitment and differentiation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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