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The role of Wnt signalling in the control of sonic hedgehog response genes
Reference
G16004
Principal Investigator / Supervisor
Dr Anne-Gaelle Borycki
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Krebs Institute for Biomolecular Researc
Funding type
Research
Value (£)
198,604
Status
Completed
Type
Research Grant
Start date
18/03/2002
End date
18/03/2005
Duration
36 months
Abstract
Sonic hedgehog (Shh) signalling is essential for the determination of paraxial mesodermal cells to the myogenic and sclerotomal lineages. However, paraxial mesodermal cells fail to respond to constitutive Shh signals prior to somite formation, thus co-ordinating cell lineage determination with somite formation. Wnt signalling is a key regulator of the initiation of Shh response in somites, and acts by controlling Gli gene expression, the mediators of Shh signalling. This project undertakes to identify the molecular mechanisms underlying this process using classical embryological approaches, as well as gain-of-function and loss-of- function studies, in the avian embryo. These studies will also shed light on the mechanisms controlling other developmental processes (hair follicle, tooth, kidney, etc) where co-operation between Wnt and Shh has been implicated.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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