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Molecular determination of the epigenetic basis of vernalization
Reference
G15996
Principal Investigator / Supervisor
Professor Dame Caroline Dean
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
181,592
Status
Completed
Type
Research Grant
Start date
04/03/2002
End date
03/09/2005
Duration
42 months
Abstract
We have recently cloned Arabidopsis (VRN) genes that mediate vernalization, the low temperature-induced promotion of flowering. Their structure and action on expression of their downstream target, FLC, suggest they function analogously to Drosophila Polycomb-Group genes, thus explaining the epigenetic basis of vernalization. To further investigate the molecular basis of vernalization, we will identify VRN protein partners using two approaches; mass-spectrometric analysis of components of protein complexes and identification of interacting proteins using yeast two-hybrid screens. We will also analyse whether VRN1 and VRN2 might link a complex to its DNA target by analysing their binding to FLC.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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