Award details

A screen for the prosenescence genes in the yeast genome

Reference	G15970
Principal Investigator / Supervisor	Professor Peter William Piper
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Structural Molecular Biology
Funding type	Research
Value (£)	201,036
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	31/10/2003
Duration	25 months

Abstract

Nondividing (Go phase) yeast cells provide a genetically tractable model of the events whereby stress resistances influence chronological life span. This project will select long-lived yeast mutants directly; exploiting the fact that this organism has a stable haploid state. It can be expected to identify genes whose loss is somewhat detrimental for propagation of the species yet beneficial for long-term maintenance of nondividing cells. Thus it should reveal the prosenescence functions that exist in a simple eukaryotic genome. In parallel work, genomic approaches will be used to identify the major changes to the yeast proteome and transcriptome during the chronological ageing of Go cells.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BB/X50024X/1 A screen for the prosenescence genes in the yeast genome

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