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Characterising the role of novel components involved in sister chromatid cohesion
Reference
G15965
Principal Investigator / Supervisor
Professor Michael Stark
Co-Investigators /
Co-Supervisors
Dr Mark Peggie
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
182,584
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
01/01/2005
Duration
36 months
Abstract
Sister chromatid cohesion is established during DNA replication and holds sister chromatids together until mitosis, when their abrupt separation in anaphase is triggered by cleavage of cohesin, the molecular glue which holds sister chromatids together. Cohesion involves highly conserved proteins and is fundamental to the faithful transmission of chromosomes during cell division. We have identified a novel Saccharomyces cerevisiae mutant (sds22-6) in which cohesion is defective. Here we propose to use budding yeast as a model system to investigate the role of Sds22p, a regulator of protein phosphatase 1 (PP1) and of PP1 itself in the process of sister chromatid cohesion, with the goal of establishing the target(s) of Sds22p/PP1 regulation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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