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Molecular evolution of sex chromosomes
Reference
G15947
Principal Investigator / Supervisor
Professor Dmitry Filatov
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
167,640
Status
Completed
Type
Research Grant
Start date
04/02/2002
End date
04/02/2005
Duration
36 months
Abstract
This project is devoted to the study of evolutionary forces playing a major role in the evolution of sex chromosomes. There are several hypotheses to be tested: (i) genetic degeneration of the Y chromosome is due to lower efficacy of selection in the non-recombining regions, suggesting higher rates of nonsynonymous substitutions in the Y-linked genes compared to the X- linked and autosomal genes; (ii) elevated mutation rates on the Y chromosome due to relaxed selection and due to the male driven evolution effect; (iii) reduced mutations rates on the X chromosome due to increased selection in the hemizygous state in males. These predictions will be tested on the recently evolved plant (Silene alba) sex chromosomes.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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