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The biological role of a novel sigma factor sigma n in the mycelial prokaryote Streptomyces coelicolor
Reference
G15940
Principal Investigator / Supervisor
Dr Gabriella Kelemen
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
188,132
Status
Completed
Type
Research Grant
Start date
01/03/2002
End date
31/07/2005
Duration
41 months
Abstract
The aim of the proposed work is to identify the biological function of a new RNA polymerase sigma factor, sigmaN, and to characterise the mechanism of its activation during morphogenesis in S. coelicolor. This will be accomplished by 1) characterising the sigN null mutant phenotype; 2) monitoring the temporal and spatial location of sigN expression; 3) positioning sigN in the hierarchy of genes controlling morphogenesis by establishing the dependence patterns of sigN expression on several whi and bld loci; 4) characterising the transcriptional activation of sigN by either BldC or by some other, yet to be identified, protein; 5) determining whether sigmaN activation also involves post- translational proteolytic processing; and 6) identifying sigmaN targets.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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