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In vivo analysis of calcium oscillations during patterning and morphological segmentation of the vertebrate mesoderm
Reference
G15805
Principal Investigator / Supervisor
Professor Caroline Brennan
Co-Investigators /
Co-Supervisors
Institution
Queen Mary University of London
Department
Sch of Biological and Chemical Sciences
Funding type
Research
Value (£)
210,248
Status
Completed
Type
Research Grant
Start date
05/08/2002
End date
04/03/2006
Duration
43 months
Abstract
Segmentation of the mesoderm underlies the segmental organisation of the axial skeleton and spinal cord and is fundamental to the functional organisation of the vertebrate body. Recently synchronised oscillations in gene expression have been suggested to underlie segmentation of the mesoderm. However, it is not known how these oscillations are initiated, maintained or indeed synchronised across a field of cells. Intracellular calcium (Ca2+) concentration also oscillates within the mesoderm of developing embryos. This project uses GFP-aequorin as a Ca2+ reporter in transgenic wildtype and mutant zebrafish embryos to investigate the role of Ca2+ oscillations during segmentation and differentiation of the mesoderm.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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