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Award details
The regulation and function of frizzled 7 during Xenopus development
Reference
G15793
Principal Investigator / Supervisor
Professor Grant Wheeler
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
180,676
Status
Completed
Type
Research Grant
Start date
01/04/2002
End date
01/04/2005
Duration
36 months
Abstract
This project will investigate the role of Wnt signalling during development and will study the regulation and function of a wnt receptor, the frizzled 7 (Xfz7) gene during Xenopus development. The project will 1) Clone the Xfz7 promoter and determine the elements leading to its complex expression pattern. 2 Study the function of Xfz7 in neural crest, heart and vascular development by expressing wildtype and dominant negative forms of the protein using an inducible expression system we have developed. 3) Develop a new approach to knockout gene expression in Xenopus using zinc finger proteins that specifically bind to the Xfz7 promoter. 4) Generate tissue specific elements that can be used to study wnt/frizzled function using an enhancer trap screen.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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