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Analysis of the developmental role of Raidd an apoptotic gene whose loss of function causes embryonic lethality
Reference
G15680
Principal Investigator / Supervisor
Dr James McWhir
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
Gene Expression and Development
Funding type
Research
Value (£)
171,724
Status
Completed
Type
Research Grant
Start date
04/05/2002
End date
04/05/2005
Duration
36 months
Abstract
The high growth (HG) mutation was discovered in mice selected for high post-weaning gain and is associated with a 30 percent average increase in adult weight. The mutation comprises a 500kb deletion in which two genes have been identified. Knockout mice have been generated at one of these loci (Raidd). Homozygous Raidd knockout mice fail in preimplantation development. The objective of the present proposal is to determine if the interaction of Raidd with the other known gene within the deletion, Socs2, can account for the fact that loss of Raidd function in HG mice is consistent with development to term.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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