BBSRC Portfolio Analyser
Award details
Molecular mechanisms of genetic exchange in lambdoid bacteriophages
Reference
G15625
Principal Investigator / Supervisor
Dr Gary John Sharples
Co-Investigators /
Co-Supervisors
Institution
Durham University
Department
Biological and Biomedical Sciences
Funding type
Research
Value (£)
185,844
Status
Completed
Type
Research Grant
Start date
01/03/2002
End date
01/03/2005
Duration
36 months
Abstract
The emergence of new pathogens as a consequence of the horizontal transfer of virulence determinants presents a serious threat to public health. Bacterial viruses infect a wide range of bacterial species and are regular vehicles for the transmission of such pernicious factors. It is now clear that bacteriophages encode their own enzymatic systems that stimulate the DNA rearrangements responsible for phage diversity and evolution. This project will investigate model systems of genetic exchange using purified lambda proteins to reconstitute the reactions in vitro and also develop a novel in vivo assay to analyse the products of recombination. These parallel approaches should yield significant insight into genetic exchange mechanisms that ultimately generate new pathogenic bacteria.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search