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The molecular basis of yeast prion strain variation
Reference
G15601
Principal Investigator / Supervisor
Professor Emeritus Mick Tuite
Co-Investigators /
Co-Supervisors
Institution
University of Kent
Department
Sch of Biosciences
Funding type
Research
Value (£)
261,332
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/10/2004
Duration
36 months
Abstract
Mammalian prions exist as different strains which are thought to be encoded by the tertiary structure of prion protein PrP. However, the molecular mechanism by which different conformers of the same protein are stably propagated remains unclear. At least two stable variants of the yeast [PSI+] prion also exist, giving rise to distinct phenotypes, but the underlying molecular differences are also unknown. Both known and newly generated [PSI+] strains will be characterised at the genetic, biochemical and cellular levels. The findings will provide important insights into the nature of prion strain specificity and further our knowledge of the underlying mechanism of transmission of prions.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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