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Regulation of embryonic stem cell differentian: the role of stem cell factor and its receptor c-Kit
Reference
G15583
Principal Investigator / Supervisor
Professor Lesley Forrester
Co-Investigators /
Co-Supervisors
Professor Anthony David Whetton
Institution
University of Edinburgh
Department
Dept of Clinical Oncology
Funding type
Research
Value (£)
174,480
Status
Completed
Type
Research Grant
Start date
15/07/2002
End date
15/07/2005
Duration
36 months
Abstract
Embryonic stem (ES) cells have been proposed as a key tool in somatic cell transplantation therapy as they can differentiate into a wide range of cell types in vitro. As stem cell factor and its receptor, c-Kit, play a critical role during development in vivo, we propose to define its role during ES cell differentiation. Wild type Kit will be specifically activated in Kit null ES cells using a novel pharmacological approach and specific cytoplasmic domains of Kit will be replaced with domains from the related Fms receptor to determine whether an instructive or permissive signal emanates from this signalling pathway. We predict that this approach will be applicable to other receptor/ligand systems and will provide clues to optimise conditions for the differentiation of ES cells into defined lineages.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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