BBSRC Portfolio Analyser
Award details
Light resetting and melatonin action on the circadian clock of the Zebrafish embryo and their impact on development
Reference
G15557
Principal Investigator / Supervisor
Professor David Whitmore
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Cell and Developmental Biology
Funding type
Research
Value (£)
203,584
Status
Completed
Type
Research Grant
Start date
01/06/2002
End date
01/06/2005
Duration
36 months
Abstract
Work to date has shown that zebrafish organs, embryos and embryonic cell lines contain a light-responsive circadian clock. The embryo responds to light within 9 hours post fertilization, before the development of any classical light-detecting structures. This project aims to a) characterise and functionally test candidate photopigments involved in this light response; b) examine the signal transduction pathways involved, with particular emphasis on intracellular calcium; and, in addition, c) examine the targets and role of melatonin production in the early zebrafish embryo. Standard molecular techniques, RNase protection, library screening, PCR and luminescent imaging approaches will be employed.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search