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The genetic control of plant mitochondrial development: map based cloning of mitochondrial mutants of Arabidopsis thaliana

Reference	G15541
Principal Investigator / Supervisor	Professor Alyson Tobin
Co-Investigators / Co-Supervisors	Dr David Logan
Institution	University of St Andrews
Department	Biology
Funding type	Research
Value (£)	249,496
Status	Completed
Type	Research Grant
Start date	25/10/2001
End date	25/10/2004
Duration	36 months

Abstract

Functional mitochondria are vital components of plant cells. Much is known about mitochondrial biochemistry and bioenergetics but the fundamental of mitochondrial developmental biology remain a mystery. We have isolated eight mitochondrial biogenesis/development mutants by a novel method involving the screening of an EMS- mutagenised Arabidopsis line transgenic for mitochondrial-targeted GFP. For six mutants, map based positional cloning will be used to locate the mutation to a region of approximately 0.1 cM Iterative complementation of the mutant phenotype with BAC and sub- BAC gene sequences will enable isolation of the wild-type genes. This project is the first study aimed at determining the genes and mechanisms controlling mitochondrial form and number in higher plants.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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