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Genetic modification of neurons to enhance extracellular matrix degradation and axonal regeneration

Reference	G15509
Principal Investigator / Supervisor	Professor Patrick Anderson
Co-Investigators / Co-Supervisors	Dr R Coffin, Professor A. R. Lieberman
Institution	University College London
Department	Cell and Developmental Biology
Funding type	Research
Value (£)	319,808
Status	Completed
Type	Research Grant
Start date	01/11/2001
End date	01/12/2004
Duration	37 months

Abstract

This project will construct HSV-1 viral vectors carrying genes for matrix metalloproteases and/or chondroitinase. It will also test the ability of the vectors to produce expression of these genes in CNS neurons and investigate the effects of gene delivery on the ability of infected neurons to regenerate their axons in the spinal cord in vivo.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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