Award details

Stem cell potency

Reference	G15381/2
Principal Investigator / Supervisor	Professor Austin Smith
Co-Investigators / Co-Supervisors	Professor Alexander Medvinsky, Dr Andrew Smith, Professor Valerie Anne Wilson
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	841,267
Status	Completed
Type	Research Grant
Start date	01/08/2006
End date	29/02/2008
Duration	19 months

Abstract

Recent reports suggest that under certain conditions adult mammalian stem cells may be able to escape lineage restriction and exhibit broad differentiation capacity. If these findings can be reproduced, understood and controlled, the implications for future healthcare strategies are considerable. However, this is a very new area of research that challenges previous orthodoxies and raises basic questions about mechanisms of cell determination and genomic programming. In this proposal we aim to determine the true incidence and nature of stem cell plasticity, to achieve a molecular definition of the stem cell state, and to examine whether the developmental potency of stem cells translates into a propensity for reprogramming by nuclear transfer.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G15381 Stem cell potency

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