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Investigating the formation of primary neurones in Xenopus: the role of retinoid signalling in neuronal determination
Reference
G15183
Principal Investigator / Supervisor
Dr Colin Sharpe
Co-Investigators /
Co-Supervisors
Institution
University of Portsmouth
Department
Sch of Biological Sciences
Funding type
Research
Value (£)
172,516
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
30/11/2004
Duration
38 months
Abstract
Retinoic acid, acting through nuclear receptors, is an important signalling system in development. We have shown that retinoid signalling (RS) is required for primary neurone formation. These neurones form a simple, functional nervous system in Xenopus embryos and provide an excellent opportunity to study the factors that determine vertebrate neuronal development. However, the mechanism by which RS influences primary neurogenesis is not yet known. Using a simple explant system that forms primary neurones in response to RS, we will explore the relationship between RS, the signals that impose A-P pattern and the mechanism of proneural prepattern formation in primary neurogenesis.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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