Award details

Development evaluation and application of phylogenetic methods for detecting molecular adaptation

Reference	G14969
Principal Investigator / Supervisor	Professor Ziheng Yang
Co-Investigators / Co-Supervisors	Dr Joseph Bielawski
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	178,764
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	30/09/2004
Duration	38 months

Abstract

Powerful likelihood models for detecting site-specific Darwinian selection along evolutionary lineages will be developed and implemented in the PAML programme package. Computer simulation will be conducted to examine the power and robustness of likelihood methods for detecting positive selection. Large data sets of viral gene sequences will be analysed to identify critical amino acids in the viral protein under diversifying selection which may be responsible for viral escape from the host immune surveillance. Genome-wide searches will be performed to understand the frequency and characteristics of genes undergoing adaptive molecular evolution.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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