Award details

Role of the novel gene glaikit in Drosophila neurogenesis

Reference	G14763
Principal Investigator / Supervisor	Professor Guy Justin Clive Tear
Co-Investigators / Co-Supervisors	Dr John Dunlop
Institution	King's College London
Department	GKT School of Medicine
Funding type	Research
Value (£)	189,848
Status	Completed
Type	Research Grant
Start date	01/04/2001
End date	01/05/2004
Duration	37 months

Abstract

The newly identified Drosophila gene glaikit (gkt) has an essential role in early neural development. gkt is expressed in the neuroectoderm and in delaminated neuroblasts, and loss of gkt activity causes severe disruption to both the neuroectoderm and neuronal development. The aim of this proposal is to characterise how glaikit functions, using a variety of molecular genetic techniques, such as characterisation of mutant allele phenotypes and directed misexpression studies. The study of gkt will be extended to other neurogenic tissues, such as the adult eye. The role of gkt is neural development will then be put into context via epistatic studies with previously characterised genes that have a role in neural determination.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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