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Translational control of maskin in early Xenopus oocytes
Reference
G14670
Principal Investigator / Supervisor
Dr Cornelia Huiberdina de Moor
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Biomedical Sciences
Funding type
Research
Value (£)
182,324
Status
Completed
Type
Research Grant
Start date
01/09/2001
End date
01/11/2004
Duration
38 months
Abstract
Maskin is an eIF4E binding protein thought to be involved in the translational repression of cyclin B1 mRNA in Xenopus oocytes. In addition, it is related to the transforming acidic coiled-coil (TACC) proteins, a new family of oncogenes. New data indicate that maskin mRNA is translationally repressed in early oocytes. This project is designed to 1. Localise the translational control element on maskin mRNA 2. Isolate, identify and clone protein(s) binding to this element. 3. Determine the function of such protein(s) by testing mutants and analysing associated proteins. This project will clarify the mechanism of translational control of maskin mRNA at the molecular level and contribute to the understanding of translational control in general.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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