Award details

Factors influencing the patterning and survival of mammalian epithelial stem cells

Reference	G14661
Principal Investigator / Supervisor	Professor Ian Mackenzie
Co-Investigators / Co-Supervisors
Institution	Cardiff University
Department	Division of Clinical Laboratory Science
Funding type	Research
Value (£)	159,548
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	31/10/2003
Duration	27 months

Abstract

These studies will examine epithelial stem cells in order to a) elucidate physiological cell renewal processes and b) develop methods of stem cell manipulation required for gene therapy and for tissue engineering. Combined techniques of cell culture, retroviral transduction, tissue reassembly and transplantation will be used to determine: a) the size and distribution of stem cell territories in a range of epithelia of differing structural complexity, b) the roles of stromal-epithelial interactions in determining regionally differing stem cell patterns, and c) how stem behaviour is influenced by the expression of genes associated with the control of cell differentiation and death.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G14661/2 Factors influencing the patterning and survival of mammalian epithelial stem cells

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