BBSRC Portfolio Analyser
Award details
Genomic modifications involved in the regulation of herpes simplex virus gene expression during latency and reactivation
Reference
G14643
Principal Investigator / Supervisor
Professor Stacey Efstathiou
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pathology
Funding type
Research
Value (£)
290,376
Status
Completed
Type
Research Grant
Start date
01/01/2001
End date
01/01/2004
Duration
36 months
Abstract
Central to our understanding of the molecular basis of herpes simplex virus (HSV) pathogenesis is clarification of the nature of genomic silencing which results in neuronal latency and the mechanism by which such repression is relieved to facilitate virus reactivation. In this proposal we wish to investigate the possible regulatory roles of histone modification and DNA methylation in controlling key lytic cycle and latently active promoters during latency and reactivation using sensitive PCR based assays. In addition we wish to define the nature of those regulatory elements which result in the continued transcription of the HSV-1 latency associated transcripts from an otherwise transcriptionally repressed genome.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search