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Regulation of stability of the AXR3/IAA17 auxin signalling protein
Reference
G14634
Principal Investigator / Supervisor
Professor Ottoline Leyser
Co-Investigators /
Co-Supervisors
Dr Stefan Kepinski
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
204,676
Status
Completed
Type
Research Grant
Start date
01/02/2001
End date
01/02/2004
Duration
36 months
Abstract
Auxin signalling has been shown to require the AXR1/TIR1 ubiquitination pathway and hence auxin is proposed to act through regulating protein stability. We have found that the AXR3/IAA17 protein is a likely target for the AXR1/TIR1 pathway. AXR3/IAA17 is a member of the Aux/IAA family of transcriptional regulators that act to mediate downstream responses to auxin. In comparable yeast systems, the phosphorylation status of such targets affects their ability to be targeted. Thus the control of auxin-induce destabilisation of Aux/IAA proteins is central to auxin signalling and provides a point for crosstalk with other important signals in plant development. In this project we will test the effects of other hormones and light on AXR3/IAA17 stability and screen for mutants with an altered AXR3/IAA17 half-life.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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