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Characterisation of the actin-like MreB protein of Bacillus subtilis and its role in cell shape deterimation
Reference
G14530
Principal Investigator / Supervisor
Professor Jeffery Errington
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Sir William Dunn Sch of Pathology
Funding type
Research
Value (£)
186,684
Status
Completed
Type
Research Grant
Start date
08/01/2001
End date
07/04/2004
Duration
39 months
Abstract
Recent work in this lab has revealed that the MreB protein of B. subtilis, which is required for the characteristic rod shape of these cells, forms a helical filamentous structure running around the circumference of the cell. This raises the possibility that bacterial cells use actin-like cytoskeletal elements to control their shape. This project is aimed at characterising the mreB gene, its protein product and interacting partners, using a combination of molecular genetics, fluorescence microscopy and biochemistry. The results may have profound implications for our understanding of the molecular basis of bacterial morphogenesis and for the evolution of the cytoskeleton.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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