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Mutation rate variation within the genome: resolving a decrepancy in estimates of the extent of male-driven evolution

Reference	G14473
Principal Investigator / Supervisor	Professor Laurence Hurst
Co-Investigators / Co-Supervisors	Professor Andrew Ward
Institution	University of Bath
Department	Biology and Biochemistry
Funding type	Research
Value (£)	215,500
Status	Completed
Type	Research Grant
Start date	01/04/2001
End date	01/04/2004
Duration	36 months

Abstract

Are males the source of most mutations? This issue is of importance in genetic counselling and in understanding the molecular clock and the causal basis of mutation. The project aims to resolve a discrepancy in molecular evolutionary estimates of the male bias in rodents: comparison of X and autosomal genes indicates that all mutations are male derived, but X-Y comparisons do not. The idea that variation in the mutation rate is adaptive is consistent with this discrepancy, but the idea that the variation is solely due to time spent in male germ line is not. The sample size of rat Y-linked genes has prevented firm conclusions. This project therefore aims to sequence rat Y-linked genes and to expand our rodent ortholog database.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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