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Expression and function of a novel gene Ankrd2 during skeletal muscle development in vivo and in vitro
Reference
G14211
Principal Investigator / Supervisor
Dr Gary Coulton
Co-Investigators /
Co-Supervisors
Institution
St George's University of London
Department
Biochemistry & Immunology
Funding type
Research
Value (£)
196,196
Status
Completed
Type
Research Grant
Start date
01/09/2001
End date
01/09/2004
Duration
36 months
Abstract
Ankrd2 is expressed exclusively in skeletal muscle, and particularly highly in slow contracting muscles. Passive stretch of skeletal muscles in vivo, a process that stimulates muscle hypertrophy, significantly increases Ankrd2 mRNA expression. Ankrd2 is a homologue of cardiac ankyrin-repeat containing protein (CARP) that regulates cardiac development and is upregulated in cardiac hypertrophy. Thus, we propose that Ankrd2 will play an important role in skeletal muscle development, muscle fibre type specialisation and muscle fibre hypertrophy. This will have impact on the basic biology of skeletal muscle as well as the development of strategies for manipulating muscle fibre phenotype for meat production and in veterinary science.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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