BBSRC Portfolio Analyser
Award details
To determine the effect of securin separin and cohesin dysfunction on genome stability and apoptosis in human cells
Reference
G14108
Principal Investigator / Supervisor
Professor Stephen Taylor
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
187,836
Status
Completed
Type
Research Grant
Start date
01/04/2001
End date
01/07/2004
Duration
39 months
Abstract
The establishment, maintenance and ultimately, the timely loss of sister chromatid cohesion is essential for genome stability as it ensures accurate chromosome segregation. In yeast, loss of cohesion is accomplished by Esp1/Cut 1 separin mediated cleavage of the Scc1 cohesion. To prevent premature loss of cohesion prior to chromosome alignment, separins are inhibited by Pds1/Cut2 securins. Cohesin, separin and securin related proteins have recently been identified in human cells but their functional roles have yet to be addressed. Therefore, we will manipulate the cohesin/separin/securin mechanism in human cells by expression of appropriate mutants and determine the effects on sister chromatid cohesion, the exit from mitosis and apoptosis.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search