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Award details
Understanding and exploiting relationships between molecular evolution and protein structure
Reference
G14076
Principal Investigator / Supervisor
Dr Nick Goldman
Co-Investigators /
Co-Supervisors
Institution
EMBL - European Bioinformatics Institute
Department
Wellcome Trust Genome Campus
Funding type
Research
Value (£)
162,134
Status
Completed
Type
Research Grant
Start date
12/08/2000
End date
11/08/2003
Duration
36 months
Abstract
Mathematical models of protein sequence evolution employed in phylogenetics ignore the effects of natural selection acting via the structure of encoded proteins. It is now possible to devise models which can incorporate and exploit knowledge of the relationships between evolution and structure. These models provide benefits to understanding of evolutionary processes and to phylogenetic inference and other comparative sequence analyses. I will continue my development of such models. I will investigate the further insights they provide into sequence evolution and the advantages they confer in phylogenetic analysis. I will implement sequence analysis methods in freely-distributed software, and apply them to exemplar problems in phylogenetic analysis.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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