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Copper-regulated gene expression in Escherichia coli
Reference
G14071
Principal Investigator / Supervisor
Professor Nigel Brown
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
236,104
Status
Completed
Type
Research Grant
Start date
01/02/2001
End date
30/08/2004
Duration
43 months
Abstract
Copper is an essential metal, but is toxic in excess. The mechanisms whereby E. coli controls intracellular copper concentrations are not understood, although some of the component regulators, copper binding proteins and transport proteins for copper resistance and normal copper management have been identified. This proposal is to use DNA array techniques to identify transcripts and gene products controlled by the chromosomal copper-responsive regulators CutR/CutS and CueR under elevated copper conditions, and to identify copper acquisition genes in order to understand better the global responses to this biologically- important metal. This system provides a model for metal homeostasis in an important model organism and will test the hypothesis that copper-responsive genes form one or more regulons.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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