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Characterisation of the link between mRNA splicing and export in higher eukaryotes
Reference
G13829
Principal Investigator / Supervisor
Professor Stuart Wilson
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
162,432
Status
Completed
Type
Research Grant
Start date
06/11/2000
End date
06/11/2003
Duration
36 months
Abstract
The nucleocytoplasmic transport of mRNA is an essential step for gene expression in all eukaryotes and intron containing pre-mRNA is actively held in the nucleus by an unknown mechanism. We have shown that the Tap mRNA export factor localises to the nuclear pore and co-localises with splicing factors within the nucleus. These unique and novel properties suggest that Tap may directly associate with the spliceosome and subsequently escort processed mRNA to the nuclear pore. In this proposal we aim to confirm that Tap associates with the spliceosome, characterise the spliceosomal components responsible for this association and investigate the mechanism for Tap release from the spliceosome.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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