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The fitness consequences of deleterious mutations and explaining sex

Reference	G13810
Principal Investigator / Supervisor	Professor Stuart West
Co-Investigators / Co-Supervisors	Professor Peter Keightley
Institution	University of Edinburgh
Department	Inst of Cell, Animal and Population Biol
Funding type	Research
Value (£)	224,800
Status	Completed
Type	Research Grant
Start date	01/10/2000
End date	30/04/2005
Duration	55 months

Abstract

Determining the rate and way in which new mutations reduce fitness per genome per generation is fundamental to numerous questions in genetics and evolutionary biology, such as why organisms reproduce sexually. However, there has recently been considerable controversy over estimates of the relevant mutational parameters. We will carry out mutation accumulation experiments on the parasitic wasp Nasonia vitripennis in order to determine: 1) the rate and way in which deleterious mutations reduce fitness and 2) if the rate at which mutations reduce fitness varies between or within populations. We shall carry out theoretical work that determines the consequences for explaining sex of variation in the fitness consequences of deleterious mutations.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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