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Determination of intrinsic versus environmental factors in the control of craniofacial myogenesis

Reference	G13795
Principal Investigator / Supervisor	Professor philippa Francis-West
Co-Investigators / Co-Supervisors	Dr Darrell Evans, Dr Lesley Robson
Institution	King's College London
Department	GKT School of Medicine
Funding type	Research
Value (£)	198,644
Status	Completed
Type	Research Grant
Start date	01/07/2001
End date	01/07/2004
Duration	36 months

Abstract

Most facial muscles are derived from unsegmented paraxial and prechordal mesoderm, in contrast to the other muscles in the body which arise from the segmented epithelial somites. Furthermore, the signalling interactions that control their differentiation appear to be unique. This project aims to determine when facial muscle cells become committed to particular myotypes i.e. fast and slow together with how and what, growth factors control this process. We will also investigate if there are intrinsic differences between muscle cells derived from the segmented somites and the unsegmented paraxial mesoderm. This project will take muscle cells derived from the segmented somites and the unsegmented paraxial mesoderm. This project will take both gain-of-function and loss-of-function approaches using developing chick and quail embryos as model systems.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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