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Functional heterogenity within transposable element families
Reference
G13767
Principal Investigator / Supervisor
Professor John Brookfield
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
School of Molecular Medical Sciences
Funding type
Research
Value (£)
113,584
Status
Completed
Type
Research Grant
Start date
01/02/2001
End date
01/02/2004
Duration
36 months
Abstract
We will investigate the impact of variation in transposition rates between transposable elements from the same family upon the phylogenetic relationship between elements. Transposable elements from a large proportion of the eukaryote genome, and an understanding of their evolution is only possible if the effects of inter-element variability in transposition rates are understood. Using a combination of analytical theory and computer simulation, we will generate quantitative predictions from models of the impact of transposition rate variation on the phylogeny of mobile DNAs from the same host. These will be used in the interpretation of the sequence variability seen in the Drosophila, Caenorhabditis and Arabidopsis genome projects, and, in particular, in the human LINE and SINE sequences.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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