Award details

A large scale screen for mutations affecting neural development in zebrafish

Reference	G13757
Principal Investigator / Supervisor	Professor Stephen Wilson
Co-Investigators / Co-Supervisors	Professor Jonathan Clarke
Institution	University College London
Department	Cell and Developmental Biology
Funding type	Research
Value (£)	404,387
Status	Completed
Type	Research Grant
Start date	01/09/2000
End date	17/09/2002
Duration	25 months

Abstract

In recent years, the zebrafish has emerged as the pre-eminent vertebrate model system for applying forward genetics to determine novel gene function. Although genetic screens have identified hundreds of genes essential for early embryonic development, there are many more yet to be isolated and characterised. We have been invited to participate in the largest ever zebrafish screen taking place at the Max-Planck Institute in Tubingen. We will screen up to 8000 thousand lines of fish for mutations affecting development of the nervous system. Mutant genes will be outcrossed and mapping crosses established to facilitate the future cloning of the mutated genes.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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