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Early development of the olfactory placode
Reference
G13701
Principal Investigator / Supervisor
Professor Andrea Streit
Co-Investigators /
Co-Supervisors
Institution
King's College London
Department
GKT School of Medicine
Funding type
Research
Value (£)
247,168
Status
Completed
Type
Research Grant
Start date
07/05/2001
End date
06/11/2004
Duration
42 months
Abstract
In birds, the olfactory organ is the last of the special sense organs to develop. It arises from two bilateral placodes in the lateral wall of the head, anterior to the eyes. The placode gives rise to nasal epithelium, the olfactory nerve and several migratory cell populations. While recent studies have focussed on neurogenesis and cell commitment within the placode, very little is known about cellular and molecular mechanisms that establish the placode territory during embryogenesis. We will combine experimental embryology and molecular approaches to identify the nasal placode before it is specified, molecular markers for it, tissues responsible for its induction and the time when inducting signals act. These studies will provide a solid basis for the identification of molecular pathways involved in the induction of the olfactory placode.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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