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Transcriptional control of mitotic cyclin expression in plant growth regulation
Reference
G13698
Principal Investigator / Supervisor
Professor Peter Doerner
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
203,876
Status
Completed
Type
Research Grant
Start date
15/08/2001
End date
14/02/2005
Duration
42 months
Abstract
Mitotic cyclin cycB1;1 abundance limits plant root organ growth without loss of developmental control (Doerner et al. Nature 1996 380 p520). The cycB1;1 promoter comprises quantitative control elements, which we propose are involved in growth control. We will analyse the role of repressor (REP) and activator (ACT) elements as effectors of growth control signal pathways by quantitative RT-PCR. Cognate binding factors will be cloned by yeast one-hybrid and proteomics methods and we will determine their function in transgenic Arabidopsis. We will identify signal pathways regulating proliferation by controlling cyclin abundance at G2/M by examining ACT and REP activity under various environmental conditions that impact growth.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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