Award details

Statistical and computational improvements to molecular phylogenetic estimation

Reference	G13580
Principal Investigator / Supervisor	Professor Ziheng Yang
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	149,456
Status	Completed
Type	Research Grant
Start date	01/04/2001
End date	01/04/2004
Duration	36 months

Abstract

Reconstruction of molecular phylogenies is an indispensable tool for extracting information from molecular sequence data. Yet it has long been recognised as a difficult statistical estimation problem. In this project, we will examine the parameter space of the estimation problem and compare different methods for evaluating the significance of the estimated phylogeny, by using analytical and simulation approaches. We will examine properties of the space of phylogenetic trees and compare different algorithms for heuristic and stochastic tree search. Both simulated and real data sets will be analysed. New algorithms/methods will be implemented in the program package PAML.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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