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Role of SUMO-1 modification in the DNA damage response
Reference
G13290
Principal Investigator / Supervisor
Dr Felicity Zoe Watts
Co-Investigators /
Co-Supervisors
Institution
University of Sussex
Department
Sch of Life Sciences
Funding type
Research
Value (£)
182,184
Status
Completed
Type
Research Grant
Start date
16/10/2000
End date
16/10/2003
Duration
36 months
Abstract
Efficient DNA damage responses are essential for the maintenance of genome integrity and cell viability. We have evidence that SUMO-1 modification of proteins is required for some of these responses. We wish to determine the role of SUMO-1 modification using two SUMO- 1 modified targets as test proteins. We will: 1) analyse SUMO-1 modification through the cell cycle and in response to DNA damage and determine whether this is dependent on the DNA integrity checkpoint proteins; 2) identify and mutate the SUMO-1 modification sites in our test proteins and analyse the phenotypes of resulting mutants; and 3) investigate stability and localisation of the modified test proteins and ask whether modification affects protein-protein interactions.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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