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Maintenance of polygenic variation and response to directional selection
Reference
G13242
Principal Investigator / Supervisor
Professor William George Hill
Co-Investigators /
Co-Supervisors
Dr Jinliang Wang
Institution
University of Edinburgh
Department
Inst of Cell, Animal and Population Biol
Funding type
Research
Value (£)
120,176
Status
Completed
Type
Research Grant
Start date
01/12/2000
End date
01/12/2003
Duration
36 months
Abstract
Understanding the mechanisms for the maintenance of polygenic variation is fundamental to comprehend the genetic basis of evolution and adaptation, and to predict the consequences of selective breeding of domestic animals and crops. The proposed work will use accumulated empirical information on new mutations and segregating alleles affecting metric traits from various experiments to construct an improved pleiotropic model for the maintenance of polygenic variation. Analytical and numerical methods will be used to obtain predictions for the genetic variance and intensity of apparent stabilising selection for a metric trait in an equilibrium population; and responses to a bottleneck in population size and to directional selection. These predictions will be compared with those from other relevant models and with empirical data available to test the validity of the pleiotropic model.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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