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Role of glutaredoxins and thioredoxins in redox regulation in yeast
Reference
G13234
Principal Investigator / Supervisor
Professor Christopher Grant
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
158,420
Status
Completed
Type
Research Grant
Start date
01/09/2000
End date
01/02/2004
Duration
41 months
Abstract
The aim of this research project is to characterise the role of redox homeostasis as an antioxidant defence against reactive oxygen species using the model eukaryote Saccharomyces cerevisiae. An increasingly important area of research is based on sulphydryl chemistry, since oxidation of -SH groups is one of the earliest observable events during oxidant-mediated damage and -SH groups play a critical role in the function of many macromolecular structures including enzymes and membrane proteins. This project will focus on the glutaredoxin and thioredoxin systems which have been implicated in cellular redox control. Two glutaredoxins have been identified in yeast and biochemical and genetic techniques will be used to elucidate their cellular functions. In particular, the functional overlap between the glutaredoxin and thioredoxin systems will be tested directly, as well as their roles in antioxidant defence.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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