Award details

RNA-based phylogenetic methods

Reference	G13151
Principal Investigator / Supervisor	Professor Magnus Rattray
Co-Investigators / Co-Supervisors	Professor Paul Higgs
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	119,604
Status	Completed
Type	Research Grant
Start date	01/10/2000
End date	01/10/2003
Duration	36 months

Abstract

Many types of RNA have a conserved secondary structure. Sequences evolve via compensatory substitutions that maintain the base pairing constraints. For phylogenetic studies rRNA is very informative. Current phylogenetic methods assume independent evolution of all sites within a gene, whereas in RNA there are strong correlations in the substitutions in paired sites. We will develop software which accounts explicitly for the influence of secondary structure on the evolutionary process. We will implement distance matrix and maximum likelihood methods with this evolutionary model. We will develop Markov Chain Monte Carlo methods to search tree space efficiently and to give statistical information on evolutionary parameters and tree properties.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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