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Molecular analysis of the novel but widely-disseminated active partition system of multidrug resistance plasmid TP228
Reference
G13032
Principal Investigator / Supervisor
Dr Finbarr Hayes
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
158,884
Status
Completed
Type
Research Grant
Start date
01/05/2000
End date
01/05/2003
Duration
36 months
Abstract
The partition of bacterial low-copy number plasmids is a highly organised spatial and temporal process which involves the interaction of plasmid-specified nucleoprotein complexes with as yet unidentified intracellular structures. In contrast to the prototypical P1 plasmid partition system, partition of the multidrug resistance plasmid TP228 requires a novel protein which epitomises an evolutionarily-distinct subgroup of the ParA superfamily and does not involve a homologue of the ParB protein which directly binds the P1 partition site. This widely-disseminated partition system will be dissected using genetic, molecular biological, and biochemical techniques with the aim of elucidating in detail the molecular mechanism by which the system operates.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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