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Molecular and developmental of the combgap gene in Drosophila

Reference	G13013
Principal Investigator / Supervisor	Dr J Whittle
Co-Investigators / Co-Supervisors	Dr Roger Phillips
Institution	University of Sussex
Department	Biology and Environmental Science
Funding type	Research
Value (£)	255,140
Status	Completed
Type	Research Grant
Start date	01/08/2000
End date	01/08/2003
Duration	36 months

Abstract

We have revealed a new role for the combgap gene in the mechanism that locates the number and position of sense organs during spatial patterning in Drosophila. Three new alleles we have recovered will help define its function during oogenesis, embryogenesis and in the imaginal discs. Genetic and molecular epistatis tests will identify the pathway within which this 'response element' operates. A P-element-based allele will permit its full molecular characterisation and provide probes to define its expression pattern, and to perturb wildtype activity. Mutations in novel interacting loci will be recovered via transposon mutagenesis, using the reporting pattern of GFP expression to select candidate mutant larvae under UV illumination. A possible integrating function of this gene in signal transduction during spatial patterning will be investigated using probe array technology.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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