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Epigenetic gene silencing in the germ line

Reference	G12997
Principal Investigator / Supervisor	Professor Colum Walsh
Co-Investigators / Co-Supervisors
Institution	University of Ulster
Department	Sch of Biomedical Sciences
Funding type	Research
Value (£)	168,036
Status	Completed
Type	Research Grant
Start date	01/11/2000
End date	01/11/2003
Duration	36 months

Abstract

Gene silencing by epigenetic means is important in suppressing transcription of endogenous retroviral elements in mice, as well as in the phenomenon of genomic imprinting, where only one parental allele of a gene is active. One theory proposes that imprinting is a by-product of a host defence mechanism which protects the integrity of the genome against invasion by selfish DNA. DNA methylation is associated with both classes of silenced gene and perturbing the level of methylation can disrupt silencing in somatic cells. We aim to test this hypothesis in the germ line of the mouse, where imprinting must be reset every generation while silencing of selfish DNA elements in maintained.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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