BBSRC Portfolio Analyser
Award details
The action of STAT3 in transcriptional determination of embryonic stem cell self-renewal
Reference
G12950
Principal Investigator / Supervisor
Professor Austin Smith
Co-Investigators /
Co-Supervisors
Dr Thomas Burdon
Institution
University of Edinburgh
Department
Inst of Stem Cell Research
Funding type
Research
Value (£)
201,682
Status
Completed
Type
Research Grant
Start date
01/04/2000
End date
01/12/2003
Duration
44 months
Abstract
Activation of the latent transcription factor STAT3 is essential for cytokine mediated self- renewal of pluripotent mouse embryonic stem (ES) cells. The critical issue now is to determine how STAT3 exerts this effect in ES cells, particularly since its activation in a variety of other cell types has quite different consequences. The purpose of this proposal is to i) identify the target genes for STAT3 in ES cells; ii) determine which of these targets are functionally relevant for self-renewal; and iii) define those features of the STAT3 protein, e.g. domains specific for interactions with other transcriptional regulators, that are critical for its function.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search