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Trans-acting modifiers of expanded triplet repeat stability
Reference
G12852
Principal Investigator / Supervisor
Professor Darren Monckton
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Molecular Genetics
Funding type
Research
Value (£)
93,271
Status
Completed
Type
Research Grant
Start date
18/11/1999
End date
18/11/2001
Duration
24 months
Abstract
Simple tandemly repeated DNA is spread throughout higher eukaryotic genomes and usually has high rates of mutation to new length alleles. Indeed, some loci have alleles with mutation rates approaching 100 percent. However, the molecular mechanisms responsible for repeat length changes and the trans-acting genes that modulate repeat instability remain largely obscure. In this study we propose to investigate the role of the mismatch repair system in modulating repeat turnover at two novel expanded repeat loci within the human genome. This goal will be achieved by the use of sensitive single molecule techniques for measuring repeat length mutations and analysis of tumour material with known defects in the mismatch repair pathway.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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