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The mechanism of intron insertion during evolution
Reference
G12767
Principal Investigator / Supervisor
Dr Nicholas Dibb
Co-Investigators /
Co-Supervisors
Dr Andrew James Newman
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
160,808
Status
Completed
Type
Research Grant
Start date
01/07/2000
End date
01/07/2003
Duration
36 months
Abstract
Although there is still much debate about the evolutionary significance and antiquity of introns, it is now accepted that during evolution many introns were inserted into genes between the G and R of the proto-splice site consensus sequence C/A A G . R that flanks extant introns. The similarity of proto-splice sites to normal splice sites raises the possibility that introns were inserted into genes during evolution through the action of the splicing machinery. Here it is proposed to test the hypothesis experimentally using the actin gene family as a model system. The results of these experiments promise to add significantly to our understanding of gene structure and gene evolution.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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